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| T-RPMS Home | Editorial Board | T-RPMS in IEEE Xplore | Early Access | Manuscript Submission | ||
| FEATURED STORIES - MARCH 2018 | ||
Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Mediumby Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Hiroshi Hashizume, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Yasumasa Okazaki, Shinya Toyokuni, Shinichi Akiyama, Shoichi Maruyama, Fumitaka Kikkawa, and Masaru Hori Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells. more... |
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Signal Amplification by Tumor Cells: Clue to the Understanding of the Antitumor Effects of Cold Atmospheric Plasma and Plasma-Activated Mediumby Georg Bauer The expression of membrane-associated catalase, SOD, and NADPH oxidase represents a characteristic feature of tumor cells and a novel target for tumor therapy. An analytical approach, based on experimentally determined responses of cells from distinct steps of oncogenesis toward defined reactive oxygen/nitrogen species (ROS/RNS) is presented. It is suggested that singlet oxygen from cold atmospheric plasma (CAP) or plasma-activated medium (PAM) triggers tumor cells to generate high concentrations of secondary singlet oxygen that inactivates their protective catalase. This reactivates intercellular ROS/RNS-dependent apoptosis-inducing signaling and also may lead to aquaporin-mediated influx of extracellular H2O2. Initial targeting of either catalase, SOD or of the FAS receptor by CAP- or PAM-derived singlet oxygen causes the same final effect. The generation of singlet oxygen is based on a complex interaction between H2O2 and peroxy-nitrite. HOCl and peroxynitrite are also potentially involved in the modulation of immunogenic cell death and thus trigger a cytotoxic T cell response that acts synergistically with the primary ROS/RNS-related effects induced by CAP or PAM. This approach might be useful to define optimal composition of CAP, to define selective CAP and PAM action, to allow for the establishment of synergistic effects and to link CAP- and PAM-related ROS/RNS effects on apoptosis with immunogenic cell death. more... |
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Model-Based Feedback Control of a kHz-Excited Atmospheric Pressure Plasma Jetby Dogan Gidon, Brandon Curtis, Joel A. Paulson, David B. Graves, and Ali Mesbah Atmospheric pressure plasma jets (APPJs) have widespread use in materials processing and biomedical applications. Safe and effective operation of hand-held APPJs is, however, highly sensitive to the intrinsic variability of plasma characteristics as well as exogenous disturbances such as variations in the separation distance between the device tip and target surface. This paper investigates feedback control of the thermal effect and intensity of a kHz-excited APPJ in helium using a proportional-integral control strategy and a model predictive control (MPC) strategy. A data-driven model of the APPJ, developed for a linear operating range using the subspace identification method, is utilized in the design of both control strategies. Real-time control experiments reveal that feedback control is crucial for effective operation of the APPJ in the presence of step disturbances in the device tip-to-surface separation distance. It is observed that the MPC strategy can more effectively regulate the multivariable dynamics of the APPJ for effective setpoint tracking and constraint handling in the face of disturbances. more... |
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A PUBLICATION OF THE IEEE NUCLEAR AND PLASMA SCIENCES SOCIETY |
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| MARCH 2018 | VOLUME 2 | NUMBER 2 | ITRPFI | (SSN 2469-7311) | ||
EDITORIAL Plasma and Cancer Treatment . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M. Laroussi, D. Graves, and M. Keidar Signal Amplification by Tumor Cells: Clue to the Understanding of the Antitumor Effects of Cold Atmospheric Plasma and Plasma-Activated Medium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G. Bauer Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, Y. Okazaki, S. Toyokuni, S. Akiyama, S. Maruyama, F. Kikkawa, and M. Hori Effect of Plasma Activated Mist on Breast Cancer Cells . . . . . . . . . . . M. El Shaer, A. Zaki, A. M. Reda, M. Adel, M. Mobasher, and S. Ali Cold Atmospheric Plasma Parameters Investigation for Efficient Drug Delivery in HeLa Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V. Vijayarangan, A. Delalande, S. Dozias, J.-M. Pouvesle, C. Pichon, and E. Robert Selective Treatment of Pancreatic Cancer Cells by Plasma-Activated Saline Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Z. Chen, L. Lin, E. Gjika, X. Cheng, J. Canady, and M. Keidar Nontarget Biomolecules Alter Macromolecular Changes Induced by Bactericidal Low-Temperature Plasma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Privat-Maldonado, Y. Gorbanev, D. O’Connell, R. Vann, V. Chechik, and M. W. van der Woude Model-Based Feedback Control of a kHz-Excited Atmospheric Pressure Plasma Jet . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D. Gidon, B. Curtis, J. A. Paulson, D. B. Graves, and A. Mesbah Physical Plasma Elicits Immunogenic Cancer Cell Death and Mitochondrial Singlet Oxygen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S. Bekeschus, A. Mueller, V. Miller, U. Gaipl, and K.-D. Weltmann Changes in Oxygen Level Upon Cold Plasma Treatments: Consequences for RONS Production . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G. Busco, F. Fasani, S. Dozias, L. Ridou, C. Douat, J.-M. Pouvesle, E. Robert, and C. Grillon Enhanced Anticancer Efficacy by Drug Chemotherapy and Cold Atmospheric Plasma Against Melanoma and Glioblastoma Cell Lines In Vitro . . . . . . . . . . . . . . . . . . . . G. Daeschlein, A. Hillmann, D. Gümbel, C. Sicher, S. von Podewils, M. B. Stope, and M. Jünger |
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