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Nuclear & Plasma Sciences Society

Distinguished Lectures

Dr. Youngho Seo

University of California, San Francisco

Lectures

Single Photon Emission Computed Tomography

Single photon emission computed tomography (SPECT) is an important radionuclide imaging technology in medicine with a large range of molecularly targeted radiopharmaceuticals available. This lecture reviews the historical development of gamma cameras that are the technological bases for SPECT imaging, and presents state-of-the-art instrumentation developments for modern applications of SPECT including imaging therapeutic radiopharmaceuticals (i.e., theranostics).

Quantitative Imaging and Dosimetry of Therapeutic Radiopharmaceuticals

Using quantitative SPECT or positron emission tomography (PET), dose calculations of therapeutic radiopharmaceuticals (i.e., beta emitters, alpha emitters, and Auger/conversion electron emitters) are possible and can hold great promise for precision medicine in radiotheranostics. This lecture will show how to ensure quantitativeness of SPECT and PET imaging, dose calculation methods and biological impacts of different types of radiation, and state-of-the-art development of imaging instrumentation and dosimetry techniques.

Hybrid Imaging

This lecture presents a historical overview of how hybrid imaging technologies such as SPECT/CT, PET/CT, and PET/MRI have evolved over time, and key clinical and preclinical applications of hybrid imaging.

About

Youngho Seo is a Professor and Director of Nuclear Imaging Physics in the Department of Radiology and Biomedical Imaging, Program Director of MS in Biomedical Imaging graduate program, Faculty at the Bakar Computational Health Sciences Institute, Program Member of the Helen Diller Family Comprehensive Cancer Center at University of California, San Francisco (UCSF), Professor in the Department of Nuclear Engineering at UC, Berkeley, Faculty of UC Berkeley – UCSF Bioengineering Graduate Program, and Physicist Faculty Scientist at Lawrence Berkeley National Laboratory. He received his bachelor’s degree in Physics from KAIST where he investigated radiation effects on satellite-borne instruments by cosmic ray as his senior thesis research project. He completed a master’s degree in Physics at University of Alabama in Huntsville, focusing on modeling ion transport by soft-electron precipitation in high-latitude ionosphere. He spent one year at UC, Irvine as a medical physics graduate student before moving to UCLA where he obtained his second master’s degree and PhD in Physics with the dissertation on a dark matter experiment using dual-phase xenon. He spent another year for postdoctoral training at UCLA in experimental neutrino physics using liquid argon. Dr. Seo joined the UCSF Physics Research Laboratory (PRL) in 2003, and was trained in medical imaging physics before joining the faculty in 2006. Dr. Seo has been Director of UCSF PRL since 2008. His primary research focus is to use and develop quantitative ionizing radiation imaging tools for a broad range of biomedical applications. He published over 200 peer-reviewed journal manuscripts, most of which focus on quantitative imaging instrumentation development and applications. He was a recipient of Distinguished Investigator Award by Academy for Radiology & Biomedical Imaging Research in 2016. For IEEE NPSS, he was part of organizing committees of several IEEE NSS/MIC/RTSD conferences, and chair of Nuclear Medical and Imaging Sciences Council (NMISC) (2024-25).

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